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RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis

Crossref DOI link: https://doi.org/10.1186/s12964-025-02278-w

Published Online: 2025-06-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Pang, Shu-jie

Jiang, Tian-yi

Wang, Nai-guo

Cui, Xiao-wen

Wang, Hui

Pan, Yu-fei

Yang, Ning

Dong, Li-wei
Funding

Funding for this research was provided by:

the special clinic project of Shanghai (20234Y0264)

the Shanghai Rising-Star Program (24QA2711800)

National Natural Science Foundation of China (82403719, 32270814)
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Article History

Received: 29 October 2024

Accepted: 28 May 2025

First Online: 10 June 2025

Declarations

:

: All animal operating procedures complied with the ethical standards of the Institutional Animal Care and Use Committee of the Naval Medical University. Animal experiments were approved by the Ethics Board of the Eastern Hepatobiliary Surgery Hospital.

: Not applicable.

: The authors declare no competing interests.

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