Bessa-Andrês, Catarina
Pinto-Cardoso, Rui
Costa, Maria Adelina
Ferreirinha, Fátima
Marinhas, José
Freitas, Rolando
Lemos, Rui
Catelas, Diogo
Vilaça, Adélio
Oliveira, António
Correia-de-Sá, Paulo https://orcid.org/0000-0002-6114-9189
Noronha-Matos, José Bernardo https://orcid.org/0000-0001-6397-2104
Funding for this research was provided by:
Fundação para a Ciência e a Tecnologia (SFRH/BD/144613/2019)
Fundação para a Ciência e a Tecnologia (SFRH/BD/135942/2018)
Fundação para a Ciência e a Tecnologia (UIDP/04308/2020)
Fundação para a Ciência e a Tecnologia (EXPL/MED-FAR/1065/2021)
Article History
Received: 16 April 2025
Accepted: 13 July 2025
First Online: 25 July 2025
Declarations
:
: Informed consent to use the biological material that would be otherwise discarded was obtained. All procedures were approved within the scope of the project “BONE-PURI(NO)AGEING– Regeneration of aged human bone through purinome activation in mesenchymal stem cells– preclinical studies”, followed by the project “BONEREGENERA - New insights of the purinome in predicting bone healing by mesenchymal stromal cells in osteoporotic patients” by the Ethics Committees of Centro Hospitalar de Vila Nova de Gaia– Espinho (registration n° 137/2018-2, endorsed on January 10, 2019) and of Gabinete Coordenador de Investigação / DEFI– Centro Hospitalar Universitário de Santo António (CHUdSA, registration n° 2021-002(001-DEFI-001-CE, endorsed on September 01, 2021), and of Instituto de Ciências Biomédicas Abel Salazar (Medical School) of the University of Porto. The investigation conforms to the principles outlined in the Declaration of Helsinki.
: Not applicable
: The authors have declared that no conflict of interest exists.