Grattarola, Margherita https://orcid.org/0000-0003-4172-7866
Pons, Nicolas https://orcid.org/0000-0003-1691-3915
Cannet, Floriane
Kaya, Müge
Kaoutari, Abdessamad El https://orcid.org/0000-0003-2334-3121
Morel, Christian https://orcid.org/0000-0001-5359-6504
Dobric, Aurélie
Borg, Jean-Paul https://orcid.org/0000-0001-8418-3382
Sequera, Celia https://orcid.org/0000-0001-6409-3910
Maina, Flavio https://orcid.org/0000-0001-6100-4695
Funding for this research was provided by:
Fondation de France
ITMO Cancer (21CD125-00, 21CD125-00)
Association Française pour l’étude du Foie
Canceropôle Provence-Alpes-Côte d’Azur
Fondation pour la Recherche Médicale
Association pour la Recherche sur le Cancer (ARCPGA2023010005822_6352)
INCa (2020-11/279/NI-KA)
Article History
Received: 3 June 2025
Accepted: 6 August 2025
First Online: 2 October 2025
Declarations
:
: All procedures involving the use of animals were performed in accordance with the European Community Council Directive of 22 September 2010 on the protection of animals used for experimental purposes (2010/63/EU). The experimental protocols were carried out in compliance with institutional Ethical Committee guidelines for animal research (comité d’éthique pour l’expérimentation animale – Comité d’éthique de Marseille) and in compliance with French law, under an agreement number E1305521, Ministère de l’Enseignement Supérieur de la Recherche et de l’Innovation. Mice were kept in a dedicated pathogen-free facility, with a light/dark cycle, and in cages with an enriched environment. Mice received Safe Complete Care Competence (SAFE A04) as complete aliment ad libitum and were housed in environmentally enriched cages under pathogen-free conditions. The project authorization of Maina laboratory relevant to this study is APAFIS #8214-2016121417291352.v5, delivered by the “Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation”.
: The authors declare no competing interests.