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Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss

Crossref DOI link: https://doi.org/10.1186/s12964-025-02450-2

Published Online: 2025-10-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhu, Yuelin

Li, Qianqian

Yu, Xin

Yang, Yun

Yang, Qian

Wang, Yongqing

Shao, Xuan

Wang, Yan-Ling
Funding

Funding for this research was provided by:

National Key Research and Development Program of China (2022YFA1103601)

National Key Research and Development Program of China (2022YFC2702400)

National Natural Science Foundation of China (82192872)

National Natural Science Foundation of China (82421003)
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Text and Data Mining valid from 2025-10-14

Version of Record valid from 2025-10-14
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Article History

Received: 13 April 2025

Accepted: 18 September 2025

First Online: 14 October 2025

Declarations

:

: The protocols for human specimen collection and animal studies were approved by the Ethics Committee at the Institute of Zoology, Chinese Academy of Sciences. All pregnant women enrolled in this study signed written informed consent.

: Not applicable.

: The authors declare no competing interests.

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