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Temporal transcriptomic profiling reveals distinct age-associated gene expression signatures in gonads under reduced insulin/IGF-1 signaling in Caenorhabditis elegans

Crossref DOI link: https://doi.org/10.1186/s12964-025-02510-7

Published Online: 2025-12-15

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kaushik, Neha

Rastogi, Soumya

Kapadia, Shivani

Jain, Vaibhav

Verma, Sonia

Pandey, Deepak

Sharma, Mona

Gupta, Surabhi

Halder, Ashutosh

Gregory, Simon

Kumar, Neeraj
Funding

Funding for this research was provided by:

Indian Council of Medical Research (5/10/FR/57/2020-RBMCH)

All-India Institute of Medical Sciences (A-1032)
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Text and Data Mining valid from 2025-12-15

Version of Record valid from 2025-12-15
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Article History

Received: 23 June 2025

Accepted: 26 October 2025

First Online: 15 December 2025

Declarations

:

: The study was approved by the Institute Ethics Committee of All India Institute of Medical Sciences (AIIMS), New Delhi (Ref No. IEC-120/06.02.2020, dated 09/03/2020). Ethical approval was obtained as part of the institutional protocol, although specific consent to participate was not needed, as the research involved a model organism, which is exempt from human ethical review requirements.

: Not applicable.

: The authors declare no competing interests.

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