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Authors
Beetler, Danielle J. https://orcid.org/0000-0003-1767-5701
Giresi, Presley https://orcid.org/0000-0002-0095-6198
Xu, Vivian https://orcid.org/0000-0002-6649-9081
McCabe, Elizabeth J. https://orcid.org/0000-0001-6711-4051
Fliess, Jessica J.
Puls, Alayna M.
Auda, Matthew E. https://orcid.org/0000-0002-3679-5365
Watkins, Molly M. https://orcid.org/0000-0001-9657-3142
Walker, Sierra A. https://orcid.org/0000-0002-9201-0833
Di Florio, Damian N. https://orcid.org/0000-0003-1619-5394
Iannotta, Dalila https://orcid.org/0000-0002-9189-4382
Whelan, Emily R. https://orcid.org/0000-0002-0410-0549
Macomb, Logan P.
Keegan, Kevin C.
Jain, Angita
Balamurugan, Varsini
Khatib, Sami
Weigel, Gabriel J. https://orcid.org/0009-0009-7410-923X
Gorelov, David J.
Pham, Anthony
Edenfield, Brandy H.
Cooper, Leslie T. Jr.
Farres, Houssam
Shapiro, Shane A.
Bruno, Katelyn A. https://orcid.org/0000-0001-8980-6059
Wolfram, Joy https://orcid.org/0000-0003-0579-9897
Fairweather, DeLisa https://orcid.org/0000-0003-3093-1810
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Funding
Funding for this research was provided by:
National Institutes of Health (TL1 TR002380)
National Institutes of Health (TL1 TR002380)
National Institutes of Health (TL1 TR002380)
National Institutes of Health (TL1 TR002380)
National Institutes of Health (TL1 TR002380)
National Institutes of Health (TL1 TR002380)
National Institutes of Health, United States (R01 HL164520)
National Institutes of Health, United States (R01 HL164520)
National Institutes of Health, United States (R01 HL164520)
National Institutes of Health, United States (R21 AI163302)
National Institutes of Health, United States (R21 AI152318)
American Heart Association, United States (23SCEFIA1153413)
Mayo Clinic Center for Regenerative Medicine in Florida
Mayo Clinic Center for Biomedical Discovery
The University of Queensland
American Heart Association (20TPA35490415)
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Article History
Received: 6 August 2025
Accepted: 22 November 2025
First Online: 26 November 2025
Declarations
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: Human biospecimens ethics statementThe collection of de-identified residual adipose material from patients that had undergone a liposuction procedure for orthopedic purposes was considered nonhuman subjects research with approval from the Mayo Clinic Biospecimens Review Group (ID: 17-010290), as previously described. 27 The collection of de-identified adipose material from patients that had undergone a vascular surgery procedure was approved by the Mayo Clinic Institutional Review Board (IRB: 21-006334); the study conformed to the principles outlined in the Declaration of Helsinki and informed and written consent was obtained from all patients.Animal care ethics statement In vivo mouse experiments were completed in accordance with recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health and with approval from the Institutional Animal Care and Use Committee (IACUC) at Mayo Clinic for all procedures (IACUC Protocol A00003748-18-R21). Mice were humanely euthanized according to standards set by the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health and in accordance with practices of the Mayo Clinic IACUC.
: No patient data.
: The authors declare no competing interests.
