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Article History

Received: 14 April 2021

Accepted: 28 September 2021

First Online: 4 November 2021

Declarations

:

: We certify that all applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during this research. Ethics approval was obtained from responsible committees in each country in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments (Belgium: Ethics Committee of the Gent University Hospital, 15/10/2007, ref.: No. EC UZG 2007/243 and 19/02/2013, No. B670201316342. Cyprus: Cyprus National Bioethics Committee, 12/07/2007, ref.: No. EEBK/EM/2007/16 and 21/Feb/2013,No.EEBK/ETI/2012/33. Estonia: Tallinn Medical Research Ethics Committee (TMREC), 14/06/2007, ref.: No. 1093 and 17/January 2013, No. 128. Germany: Ethic Commission of the University of Bremen, 16/01/2007 and 11/12/2012. Hungary: Medical Research Council, 21/Jun/2007, ref.: 22–156/2007-1018EKU and 18/12/2012, 4536/2013/EKU. Italy: Ethics Committee of the Local Health Authority (ASL) in Avellino, 19/06/2007, ref.: No. 2/CE and 18/Sep/2012, No. 12/12. Spain: Ethics Committee for Clinical Research of Aragon (CEICA), 20/06/2007, ref.: No. PI07/13 and 13/Feb/2013, No. PI13/0012. Sweden: Regional Ethics Research Board in Gothenburg, 30/07/2007, ref.: No. 264–07 and 10/Jan/2013, No. 927–12). All parents or legal guardians of the participating minor children gave written informed consent. Children older than 16 years provided written informed consent, while children aged 12 and over gave a simplified written consent. Younger children gave oral consent for examinations and sample collection.

: Not applicable.

: The authors have no conflicts of interest to declare.