Ascierto, Paolo A. http://orcid.org/0000-0002-8322-475X
Ribas, Antoni
Larkin, James
McArthur, Grant A.
Lewis, Karl D.
Hauschild, Axel
Flaherty, Keith T.
McKenna, Edward
Zhu, Qian
Mun, Yong
Dréno, Brigitte
Clinical trials referenced in this document:
Documents that mention this clinical trial
Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: a pooled analysis of four clinical trials
https://doi.org/10.1186/s12967-020-02458-x
The European Medicines Agency review of vemurafenib (Zelboraf®) for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma: Summary of the scientific assessment of the Committee for Medicinal Products for Human Use
https://doi.org/10.1016/j.ejca.2013.01.015
Documents that mention this clinical trial
Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: a pooled analysis of four clinical trials
https://doi.org/10.1186/s12967-020-02458-x
The European Medicines Agency review of vemurafenib (Zelboraf®) for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma: Summary of the scientific assessment of the Committee for Medicinal Products for Human Use
https://doi.org/10.1016/j.ejca.2013.01.015
Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting De Novo Resistance Using BH3 Mimetics
https://doi.org/10.1371/journal.pone.0101286
Documents that mention this clinical trial
Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: a pooled analysis of four clinical trials
https://doi.org/10.1186/s12967-020-02458-x
MEK1/2 inhibitors in the treatment of gynecologic malignancies
https://doi.org/10.1016/j.ygyno.2014.01.008
Documents that mention this clinical trial
Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: a pooled analysis of four clinical trials
https://doi.org/10.1186/s12967-020-02458-x
Recent advances in melanoma systemic therapy. BRAF inhibitors, CTLA4 antibodies and beyond
https://doi.org/10.1016/j.ejca.2013.06.027
Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study
https://doi.org/10.1186/s12967-017-1246-0
MEK1/2 inhibitors in the treatment of gynecologic malignancies
https://doi.org/10.1016/j.ygyno.2014.01.008
Funding for this research was provided by:
F. Hoffmann-La Roche Ltd.
Article History
Received: 26 June 2020
Accepted: 22 July 2020
First Online: 3 August 2020
Ethics approval and consent to participate
: Each trial was conducted in accordance with the Declaration of Helsinki and the principles of Good Clinical and Laboratory Practice and with the approval of appropriate ethics committees. All participants provided written informed consent.
: Not applicable.
: PAA reports consulting/advisory role for Bristol-Myers Squibb, Roche/Genentech, Merck Sharp & Dohme, Array, Novartis, Merck Serono, Pierre Fabre, Incyte, Genmab, NewLink Genetics, MedImmune, AstraZeneca, Syndax, Sun Pharma, Sanofi, Idera, Ultimovacs, Sandoz, and Immunocore; research funding from Bristol-Myers Squibb, Roche/Genentech, and Array; and travel, accommodations, or expenses from Merck Sharp & Dohme. AR reports honoraria from Amgen, Chugai, Genentech, Merck, and Novartis; consulting/advisory role for Amgen, Chugai, Genentech, Merck, and Novartis; and stock or other ownership in Advaxis, Arcus, Bioncotech, Compugen, CytomX, Five Prime, FLX-Bio, ImaginAb, IsoPlexis, Kite-Gilead, Merus, Rgenix, Lutris, PACT Pharma, and Tango Therapeutics. JL reports honoraria from Achilles Therapeutics, AstraZeneca, Boston Biomedical, Bristol-Myers Squibb, Eisai, EUSA Pharma, GlaxoSmithKline, Ipsen, Imugene, Incyte, Onctura, Kymab, Merck Serono, Merck Sharp & Dohme, Nektar, Novartis, Pierre Fabre, Pfizer, Roche/Genentech, Secarna, and Vitaccess; consulting/advisory role for Achilles Therapeutics, AstraZeneca, Boston Biomedical, Bristol-Myers Squibb, Eisai, EUSA Pharma, GlaxoSmithKline, Ipsen, Imugene, Incyte, Onctura, Kymab, Merck Serono, Merck Sharp & Dohme, Nektar, Novartis, Pierre Fabre, Pfizer, Roche/Genentech, Secarna, and Vitaccess; research funding from Achilles Therapeutics, Aveo, Bristol-Myers Squibb, Merck Sharp & Dohme, Nektar, Novartis, Pfizer, Roche/Genentech, Covance, and Immunocore. GAM reports steering committee membership and principal investigator roles for Roche/Genentech. KDL reports a consulting/advisory role for Roche, Merck, Regeneron, and Array; and research funding from Roche, Merck, Array, Regeneron, Iovance, Incyte, Neon, Nektar, and Bristol-Myers Squibb. AH reports honoraria from Amgen, Bristol-Myers Squibb, Merck Serono, Merck Sharp & Dohme, Philogen, Pierre Fabre, Provectus, Regeneron, Roche, OncoSec, Sanofi-Genzyme, and Novartis Pharma; consulting/advisory role for Amgen, Bristol-Myers Squibb, Merck Serono, Merck Sharp & Dohme, Philogen, Pierre Fabre, Provectus, Regeneron, Roche, OncoSec, Sanofi-Genzyme, and Novartis Pharma; research funding from Amgen, Bristol-Myers Squibb, Merck Serono, Merck Sharp & Dohme, Philogen, Pierre Fabre, Provectus, Regeneron, Roche, Sanofi-Genzyme, and Novartis Pharma. KTF reports consulting/advisory role for Roche, X4 Pharmaceutical, Apricity, PIC Therapeutics, Sanofi, Amgen, Asana, Adaptimmune, Fount Therapeutics, Aeglea, Array BioPharma, Shattuck Labs, Arch Oncology, Tolero Pharmaceuticals, Oncoceutics, Fog Pharma, Neon Therapeutics, Tvardi, Novartis, Genentech, Bristol-Myers Squibb, Merck, Takeda, Verastem, Checkmate, Boston Biomedical, Pierre Fabre, Cell Medica, and Debiopharm; research funding from Roche; stock ownership for Loxo Oncology, Clovis Oncology, Strata Oncology, Vivid Biosciences, X4 Pharmaceuticals, Apricity, PIC Therapeutics, Fount Therapeutics, Shattuck Labs, Oncoceutics, Fog Pharma, and Tvardi; and served on the board of directors for Loxo Oncology, Clovis Oncology, Strata Oncology, and Vivid Biosciences. EM and YM report employment with Genentech and stock or other ownership in Genentech. QZ reports employment with Edwards Lifesciences; stock or other ownership in Edwards Lifesciences; and a consulting/advisory role with Genentech. BD reports honoraria from Bristol-Myers Squibb, Roche, Novartis, and Pierre Fabre; consulting/advisory roles for Bristol-Myers Squibb, Roche, Novartis, and Pierre Fabre; research funding from Bristol-Myers Squibb and Roche; and travel, accommodations, or expenses from Roche and Bristol-Myers Squibb.