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Article History

Received: 27 March 2020

Accepted: 28 July 2020

First Online: 8 August 2020

Ethics approval and consent to participate

: The MRI quantification of CSF volume experiment in the monkey, ⁶⁴Cu-DOTA and ^99mTc-DTPA/Malat1 ASO experiments were performed at MPI Research and the study procedures were reviewed and approved by the Institutional Animal Care and Use Committee at MPI Research prior to the start of the study. The ⁶⁴Cu-DOTA study was performed under approved protocols 1881-091 and 1881-100. The ^99mTc-DTPA/Malat1 ASO experiment was performed under approved protocol 1881-102 and the MRI experiment was performed under protocols 1881-098 and 1881-100. The Mapt ASO experiment was performed at Northern Biomedical Research under a protocol approved by their Institutional Animal Care and Use Committee, specifically protocol number 004-031. All three of these studies complied with the U.S. Department of Agriculture’s Animal Welfare Act (9 CFR Parts 1, 2, and 3) and the Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, National Academy Press, Washington, D.C., 2011. Both MPI Research and Northern Biomedical Research are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).

: Not applicable.

: CM., B.F., B.P., L.T., B.D-S., H.K. and E.S. are employees of and stockholders in Ionis Pharmaceuticals, Inc. J.H. is a co-founder and managing partner of Invicro as well as an equity shareholder. J.H., J.M.S., and R.P. were employees of Invicro at the time that this work was performed, and J.M.S. is currently an employee of Biogen Inc., L.H. was an employee of Biogen at the time that this work was performed and is currently an employee of Kaiser Permanente, D.A.W, and N.C. are employees of Biogen. A.V. was an employee of Biogen at the time that this work was performed, and is currently an employee of Codiak Pharmaceuticals, Inc.