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Article History

Received: 11 July 2022

Accepted: 18 August 2022

First Online: 30 September 2022

Declarations

:

: The study was approved by the regional ethical committee (Regional Ethical Committee of Liguria—registration number 068/2019). It was performed according to the Declaration of Helsinki, Good Clinical Practice and local ethical guidelines. All living patients enrolled in the study signed a written informed consent and all medical data used in this study were anonymized.

: Informed consent was obtained from all the patients enrolled in the study.

: Dr Rebuzzi received honoraria as speaker at scientific events BMS, Amgen, GSK. Dr Buti received honoraria as speaker at scientific events and advisory role by BMS, Pfizer, MSD, Ipsen, Roche, Eli Lilly, AstraZeneca, Pierre-Fabre, Novartis. Dr Fornarini services advisory boards for Astellas, Janssen, Pfizer, Bayer, MSD, Merck and received travel accomodation from Astellas, Janssen, Bayer. Dr Rescigno services advisory boards for MSD, AstraZeneca and Janssen. Dr Banna reports personal fees from AstraZeneca, Janssen-Cilag, Boehringer Ingelheim, Roche and non-financial support from BMS, AstraZeneca, MedImmune, Pierre Fabre, IPSEN. Dr De Giorgi services as advisory/board member of Astellas, Bayer, BMS, IPSEN, Janssen, Merck, Pfizer, Sanofi, received research grant/funding to the institution from AstraZeneca, Roche, Sanofi and travel/accommodations/expenses from BMS BMS, IPSEN, Janssen, Pfizer. Dr Zucali reports outside the submitted work personal fees for advisory role, speaker engagements and travel and accommodation expenses from Merck Sharp & Dohme (MSD), Astellas, Janssen, Sanofi, Ipsen, Pfizer, Novartis, Bristol Meyer Squibb, Amgen, AstraZeneca, Roche, and Bayer. ​Dr Procopio services advisory boards/consulting for Astellas, AstraZeneca, BMS, Janssen, IPSEN, Merk, MSD, Novartis, Pfizer. Dr Sorarù services advisory boards/consulting for Janssen, received research funding from Janssen and received travel accomodation from Ipsen, BMS, Janssen, Pfizer, Astellas Pharma. Dr Cortellini received speaker fees and grant consultancies by Astra Zeneca, MSD, OncoC4 and EISAI. Dr Morelli received grants from MSD, Pfizer. The other authors have no conflicts of interest to disclose.