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Article History

Received: 24 April 2024

Accepted: 11 August 2024

First Online: 28 August 2024

Declarations

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: Human material: PDAC patient-derived xenografts (PDXs): A6L, 185, 215, 253, 265 and 354 were obtained from the Biobank of the Spanish National Cancer Research Centre (CNIO), Madrid, Spain (MTAs #CNIO20-027, #CNIO21-253). PDAC PDX-derived cultures were established as previously described []. Pancreatic circulating tumor cells (CTCs): The metastatic model CTCA was established from circulating tumor cells and obtained through the Barts Pancreas Tissue Bank of the Barts Cancer Institute (; BCI, London, United Kingdom; 2019/02/IISA/PS/E/Cellcultures). In vivo experiments: Mice were housed according to institutional guidelines and all experimental procedures were performed in compliance with the institutional guidelines for the welfare of experimental animals as approved by the University of Zaragoza Ethics Committee (CEICA PI22/17, PI35/19, PI41/20) and in accordance with the guidelines for Ethical Conduct in the Care and Use of Animals as stated in The International Guiding Principles for Biomedical Research involving Animals, developed by the Council for International Organizations of Medical Sciences (CIOMS).

: The authors declare that they have no competing interests.