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Authors
Tan, Yiling
Wang, Jiayu
Liu, Chunming
Wu, Shujuan
Zhou, Mengqi
Zhang, Yan
Yin, Tailang
Yang, Jing https://orcid.org/0000-0002-3286-0772
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Funding
Funding for this research was provided by:
Key Technologies Research and Development Program (2023YFC2705700)
Innovative Research Group Project of the National Natural Science Foundation of China (No. 82271672)
Renmin Hospital of Wuhan University (JCRCWL-2022-001, JCRCYG-2022-009)
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Article History
Received: 23 July 2024
Accepted: 25 September 2024
First Online: 10 October 2024
Declarations
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: This study included 15 patients who terminated their pregnancies for non-medical reasons (normal pregnancy, NP group) and 12 patients with URSA two or more times (URSA group). The study enrolled patients treated in Renmin Hospital of Wuhan University from October,2021 to January,2023. Patients in the NP group had a history of more than one live birth, with no history of adverse pregnancy, including spontaneous abortion, eclampsia, and preterm birth. URSA patients with the following characteristics were excluded: [] abnormal anatomical structure of the reproductive tract [], chromosomal abnormalities in parents or embryos [], infectious diseases, and [] endocrine or metabolic diseases. These patients had an abortion between seven and nine weeks of gestation to terminate the unintended pregnancy. All procedures were approved by the Ethics Committee of Renmin Hospital of Wuhan University (No. WDRY2021-K044). Patients with a normal pregnancy and URSA who underwent an induced abortion provided written informed consent. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.
: All authors approved the final manuscript and the submission to this journal.
: The authors declare no competing interests.
: The 8-week-old female and male C57BL/6 mice were kept in a specific pathogen-free (SPF) environment under standard environmental conditions (22–24 °C and 60–70% relative humidity). All protocols and experiments of mice were approved by the Animal Care and Use Committee of Wuhan University (Approval number: 20190710).
