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Authors
Shi, Yi
Huang, Maoping
Zhou, Wanmei
Zhao, Yi
Zhao, Jiuying
Zhong, Bei
French, Samuel W.
Tang, Xiaoping
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Funding
Funding for this research was provided by:
the National Key Research and Development Program of China (No. 2022YFC2304800)
the Guangzhou Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes (No. 2021KSYS009)
the Affiliated Qingyuan Hospital of Guangzhou Medical University (202301-205)
the Fifth Affiliated Hospital of Guangzhou Medical University. (2024SRP133)
the Key-Area Research and Development Program of Guangdong Province (No. 2022B1111020002)
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Article History
Received: 1 March 2025
Accepted: 15 May 2025
First Online: 3 June 2025
Declarations
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: Formalin-fixed paraffin-embedded (FFPE) liver biopsies from patients with HCC (n = 10) were obtained from the archives of Qingyuan Affiliated Hospital of Guangzhou Medical University, following Institutional Review Board approval (IRB-2022–094). Cases with significant MDBs (n = 3) were selected and evaluated by experienced pathologists. The study adhered to the principles of the Declaration of Helsinki, with data analyzed anonymously. All procedures involving human sample collection were approved and registered at Medicalresearch.org.cn by the tissue bank of the Qingyuan Affiliated Hospital of Guangzhou Medical University (ChiCTR2400084248). Informed consent was obtained from all participants.Animal experimental protocols were approved by the Animal Care Committee of Guangzhou Medical University (GY2022144 and GY2022-101).
: Informed consent was obtained from all participants. The study adhered to the principles of the Declaration of Helsinki, and all procedures involving human samples were approved and registered at Medicalresearch.org.cn by the tissue bank of the Qingyuan Affiliated Hospital of Guangzhou Medical University (ChiCTR2400084248). The work has not been published or is under consideration elsewhere. All the authors agree to submit the manuscript.
: The authors declare that they have no competing interests.
