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Impact of intra-tumoral microbiome on the efficacy of neoadjuvant immunochemotherapy in patients with locally advanced oral squamous cell carcinoma

Crossref DOI link: https://doi.org/10.1186/s12967-025-06881-w

Published Online: 2026-05-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zheng, Xiaojuan

Wu, Wenjie

Zhang, Ye

Zhang, Jie

Ma, Fei https://orcid.org/0000-0001-9432-1902
Funding

Funding for this research was provided by:

Beijing Xisike Clinical Oncology Research Foundation (Y-MSDPU2022-0547)

the Clinical Research Foundation of Peking University School and Hospital of Stomatology (PKUSS-2023CRF1012)

the Cultivation project of Medical Oncology Key Foundation of Cancer Hospital Chinese Academy of Medical Sciences (CICAMS-MOCP2022015)

the National Key Research and Development Program of China (2022YFC2504200)

the Medical Oncology Innovation Team of Cancer Hospital Chinese Academy of Medical Sciences ,Y&M Cultivation project of Cancer Hospital Chinese Academy of Medical Sciences (CICAMS-MOY&M-202401)
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Text and Data Mining valid from 2026-05-01

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Article History

Received: 16 January 2025

Accepted: 15 July 2025

First Online: 1 May 2026

Declarations

:

: The specimen and clinical data were obtained from two studies approved by the Ethics Committee of Peking University School and Hospital of Stomatology (IRB number: PKUSSIRB-202053013, PKUSSIRB-202170179) and registered at Chictr.org.cn (ChiCTR2200056354). Detection of microbiota of tissue specimens obtained from patient was approved by the Medical-Ethical Committee of Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (NCC4494).

: All authors have approved the manuscript and provided consent for publication.

: The authors declare no competing interests.

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