Wei, Hongxiang
Shi, Kai
Huang, Daoxiang
Lin, Huangfeng
Wang, Shenglin
Chen, Xuanwei
Zhang, Wenming
Funding for this research was provided by:
Natural Science Foundation of Fujian Province (2022J01697)
Fujian Province Financial Subsidy Health Special Project ( (BPB-2024CXW)
Article History
Received: 30 March 2025
Accepted: 21 July 2025
First Online: 31 October 2025
Declarations
:
: This paper has not been published in any other journal, neither is it presented in any meeting. All authors have approved the manuscript and agree with submission to Journal of orthopaedic translation. The authors have no competing interests to declare.
: Public datasets analyzed in this study are available in the GEO (accession: GSE21257, GSE19276, GSE126209, GSE42352) and TARGET-OS repositories. Restrictions apply to clinical data from the 62 patients due to privacy and ethical regulations. Deidentified datasets generated during this study are available from the corresponding author (Wenming Zhang: 1019040069@qq.com) upon reasonable request, subject to approval by the Institutional Review Board of First Affiliated Hospital of Fujian Medical University (IRB# MTCA, ECFAH Of FMU [2015]084-2). Reagent-related data (e.g., E7820 inhibitor protocols) are included in the Methods section.