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Authors
Tian, Linghan
Han, Zhibo
Jiang, Ming
Yang, Yi
Ju, Yunhe
Zhang, Ming
Chen, Yan
Gu, iaming
Song, Ying
Bao, Lei
Song, Qian
Yuan, Lu
Li, Zongjin
Gu, Jundong
Han, Zhongchao
Dong, Jian https://orcid.org/0000-0003-2955-0770
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Clinical Trials BETA
Clinical trials referenced in this document:
chictr2400094739 at Chinese Clinical Trial RegistryDocuments that mention this clinical trial
Topical application of a placental mesenchymal stem cell-embedded biomaterial hydrogel accelerates the repair of radiation-induced skin damage: a double-blind randomized phase II clinical trial
https://doi.org/10.1186/s12967-025-07060-7
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Funding
Funding for this research was provided by:
Development of mesenchymal stem cell stemness standards and therapeutic product development ((202402AA310265))
Key Laboratory of Cell Therapy Technology Transformation Medicine of Yunnan Province, Grant/Award (2015DG034)
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Article History
Received: 17 June 2025
Accepted: 26 August 2025
First Online: 6 October 2025
Declarations
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: This study adheres to the Declaration of Helsinki and Good Clinical Practice (GCP) guidelines to ensure the highest ethical standards. Ethical approval was secured from the Institutional Review Board of Yunnan Cancer Hospital prior to the commencement of the study (Approval Number: YJZ202102). All participants provided written informed consent before being enrolled in the study. The clinical trial is registered with the Chinese Clinical Trial Registry (Approval Number: ChiCTR2400094739).
: Not applicable.
: The authors declare that Zhibo Han, Zongjin Li, Jundong Gu, and Zhongchao Han are affiliated with Beijing Health-Biotech Stem Cell Technology Co. which developed and supplied the placental mesenchymal stem cells (PMSCs) embedded biomaterial hydrogels used in this study. This affiliation may be seen as a potential conflict of interest. However, this clinical study was led by Yunnan Cancer Hospital, and the entire clinical study process was completed jointly by the hospital staff and the CRO hired by the hospital. Strict scientific and ethical standards were followed, and the authors affirm that the data analysis, interpretation of results, and conclusions were objective and free from bias.
