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Integrated single-cell RNA-seq analysis reveals that EZH2 regulates the MIF-CD74 axis to modulate T cell activation and exhaustion in hepatocellular carcinoma

Crossref DOI link: https://doi.org/10.1186/s12967-025-07071-4

Published Online: 2025-10-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhou, Yangyang

Xu, Yi

Ye, Mengfan

Xing, Jiayi

Chen, Di

Ahmed, AL-Ameer Wail Hussein

Ali, Al-Rahabi Rehab Abdullah Mohammed

Pan, Chenwei

Yang, Xiangchou https://orcid.org/0000-0002-9312-3290
Shen, Zan
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (81772521)

National key research and development program of China (2023YFC2411405)
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Text and Data Mining valid from 2025-10-01

Version of Record valid from 2025-10-01
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Article History

Received: 28 May 2025

Accepted: 31 August 2025

First Online: 1 October 2025

Declarations

:

: All animal experiments were carried out according to the institutional guidelines and approved by Animal Care and Use Committee (IACUC) in Shanghai Yishang Biotechnology Co., Ltd. (IACUC-2024-Mi-070).

: Not applicable.

: The authors declare no competing interests.

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