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Integrated multi-omics reveals glycolytic gene signatures of lung adenocarcinoma brain metastasis and the impact of Rac2 lactylation on immunosuppressive microenvironment

Crossref DOI link: https://doi.org/10.1186/s12967-025-07207-6

Published Online: 2025-10-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yi, Yali

Xu, Wenjie

Yu, Houjian

Luo, Yuxi

Zeng, Fujuan

Luo, Daya

Zeng, Zhimin

Xiong, Le

Huang, Long

Cai, Jing

Liu, Anwen https://orcid.org/0000-0001-5279-1068
Funding

Funding for this research was provided by:

Wu Jieping Medical Foundation (320.6750.2023-16-8)

National Natural Science Foundation of China (82260628)

National Natural Science Foundation of China (82060577)
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Text and Data Mining valid from 2025-10-29

Version of Record valid from 2025-10-29
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Article History

Received: 29 June 2025

Accepted: 18 September 2025

First Online: 29 October 2025

Declarations

:

: The experiment was approved by the Ethics Committee of Second Affiliated Hospital of Nanchang University Medical Research and the Nanchang University Approval for Research Involving Animals (20221031140).

: Not applicable.

: The authors declare that they have no competing interests.

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