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Article History

Received: 9 April 2025

Accepted: 1 October 2025

First Online: 18 November 2025

Declarations

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: GWAS summary statistics were used without access to individual-level data, and single cell-type RNA sequencing data were obtained from public souces. Animal experiments were approved by the Animal Experimentation Ethics Committee of The Second Affiliated Hospital of Zhejiang University (approval number: 2,024,236). The human study complied with the Declaration of Helsinki and was approved by the Ethics Review Committee of The Second Affiliated Hospital of Zhejiang University (approval number: 2,020,394). All participants provided written informed consent before participation.

: All participants provided written informed consent.

: The authors declare no conflicts of interest related to this article.