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Artificial intelligence-based tumor-stroma ratio quantification reveals prognostic value and stromal-driven immunosuppression in colorectal cancer: an international validation study

Crossref DOI link: https://doi.org/10.1186/s12967-026-07681-6

Published Online: 2026-01-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ye, Huifen

Zhao, Ke

Cui, Yanfen

Li, Zhenhui

Zhang, Huan

Zhong, Min-Er

Fan, Chuanwen

Huang, Haitao

Hawkins, Nicholas J.

Ward, Robyn L.

Sun, Xiao-Feng

Song, Jinming

Liu, Zaiyi

Jonnagaddala, Jitendra

Tong, Tong

Yao, Su https://orcid.org/0000-0003-1574-6836
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Text and Data Mining valid from 2026-01-24

Version of Record valid from 2026-02-17
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Article History

Received: 22 October 2025

Accepted: 31 December 2025

First Online: 24 January 2026

Declarations

:

: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Research Ethics Committees of Guangdong Provincial People’s Hospital (KY2023-046–01), with the need for informed consent waived for this retrospective study.

: Not applicable.

: The authors declare that they have no competing interests.

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