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Epigenetic alterations of AKT1 orchestrate a metabolic reprogramming in advanced lipedema: translational insights from an integrated multi-omics study

Crossref DOI link: https://doi.org/10.1186/s12967-026-07726-w

Published Online: 2026-01-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Santella, Biagio

Salvati, Annamaria

Papp, Alexander

D’Ursi, Annamaria

Memoli, Domenico

Mingo, Monica

Pulai, Christoph

Marino, Carmen

Rastrelli, Luca

D’Elia, Maria

Nassa, Giovanni

Schiavo, Luigi https://orcid.org/0000-0003-3639-6847
Funding

Funding for this research was provided by:

PNRR-MUR NextGenerationEU PRIN 2022 (D53D23007790001)

PNRR-MUR NextGenerationEU PRIN-PNRR 2022 (D53D23016530001)

National Biodiversity Future Center (CN00000033)
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Text and Data Mining valid from 2026-01-24

Version of Record valid from 2026-02-17
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Article History

Received: 3 November 2025

Accepted: 10 January 2026

First Online: 24 January 2026

Declarations

:

: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. The study was reviewed and approved by the ethics committee of the Land Salzburg. All study participants gave written informed consent and were informed about the study (EK Nr: 1023/2024).

: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

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