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Tumor-associated macrophage-specific LRRFIP1 promotes M2 macrophage polarization and progression of colorectal cancer via activation of the PI3K pathway

Crossref DOI link: https://doi.org/10.1186/s12967-026-07759-1

Published Online: 2026-01-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Mu, Silong

Zhang, Shuomin

Wang, Maihuan

Yuan, Xinpu

Zou, Guijun

Zhang, Chaojun

Cao, Zhen
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Text and Data Mining valid from 2026-01-29

Version of Record valid from 2026-02-04
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Article History

Received: 24 July 2025

Accepted: 10 December 2025

First Online: 29 January 2026

Change Date: 15 February 2026

Change Type: Update

Change Details: Article updated to correct the affiliation numbering in author names

Declarations

:

: All animal experiments were completed according to procedures that comply with our university’s guidelines for the ethical treatment of Laboratory Animals, and all experiments were performed with the permission of the Institutional Animal Care and Use Committee (approval number JLHK-20240112-01). The investigation was approved by the Ethics Committee of Chinese PLA General Hospital (approve number: HZKY-PJ-2024-26). Tumor-node-metastasis (TNM) staging was performed according to American Joint Committee on Cancer (AJCC) standards.

: Written informed consent was obtained from each patient.

: The authors declare there is no conflict of interest regarding the publication of this paper.

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