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Integrated single-cell and spatial transcriptomic analysis reveals mCAF-SPP1⁺ macrophage-T cell crosstalk shaping immunosuppressive niches in colorectal cancer liver metastasis

Crossref DOI link: https://doi.org/10.1186/s12967-026-07978-6

Published Online: 2026-03-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chang, Mengyao

Feng, Mingyang

Lei, Yanna

Wang, Yingyuan

Bai, Liangliang

Wang, Yongsheng https://orcid.org/0000-0001-7450-0006
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Text and Data Mining valid from 2026-03-10

Version of Record valid from 2026-04-17
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Article History

Received: 9 December 2025

Accepted: 26 February 2026

First Online: 10 March 2026

Declarations

:

: This study used only de-identified data from publicly available databases (TCGA, GEO, and the Stanford DNA Discovery dataset). No new human participants were recruited, and additional ethics committee approval or informed consent was not required.

: Not applicable.

: All analyses used de-identified data; no direct identifiers were used or shared.

: The authors declare that they have no competing interests.

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