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FNDC5/irisin ameliorates diabetes-associated cognitive dysfunction via αVβ5-cAMP signaling to regulate oxidative stress, neuroinflammation and synaptic plasticity

Crossref DOI link: https://doi.org/10.1186/s12967-026-08066-5

Published Online: 2026-03-28

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ma, Mei

Tian, Yue

Yin, Ruiying

Jing, Guangchan

Zhang, Mengren
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Text and Data Mining valid from 2026-03-28

Version of Record valid from 2026-05-07
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Article History

Received: 26 November 2025

Accepted: 20 March 2026

First Online: 28 March 2026

Declarations

:

: All procedures were reviewed and approved by the Institutional Animal Care and Use Committee of Beijing Huafukang Biotechnology Co., Ltd. (approval number HFK-AP-20240812) and conducted in accordance with the ARRIVE guidelines.

: All authors have read and approved the final manuscript.

: The authors have no relevant financial or non-financial interests to disclose.

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