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Dual immunosuppression mechanism induced by PTP1B in colorectal cancer: upregulation of PD-L1 by FOXO1/miR-34C/c-MYC axis and inhibition of the infiltration of CD8(+) T cell by downregulating of CXCL11

Crossref DOI link: https://doi.org/10.1186/s12967-026-08189-9

Published Online: 2026-04-28

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Zihan

Cai, Xin

Pei, Gen

Cheng, Xianshuo

Tian, Linghan

Zhou, Yao

Shi, Wenjun

Yang, Jun

Dong, Jian https://orcid.org/0000-0003-2955-0770
Li, Yunfeng
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Text and Data Mining valid from 2026-04-28

Version of Record valid from 2026-06-16
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Article History

Received: 20 January 2026

Accepted: 12 April 2026

First Online: 28 April 2026

Declarations

:

: Clinic samples were obtained from Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University) and used in accordance with the policies of the institutional review board of the hospital (NO. KYLX2024-101). All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals (8th edition, published by the National Academies Press, Washington, DC, USA), followed the Yunnan Province Regulations on Laboratory Animal Management and approved by the Animal Ethics Committee of Kunming Medical University (Approval No.DWSP202504014).

: Not applicable.

: Not commissioned; externally peer reviewed. Generative AI and AI-assisted technologies were NOT used in the preparation of this work

: The authors declare no competing interests.

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