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Integrative single-cell and spatial transcriptomic analysis reveals a lactate-driven crosstalk between NFATc4⁺ tumor cells and SPP1⁺ macrophages in glioblastoma

Crossref DOI link: https://doi.org/10.1186/s12967-026-08555-7

Published Online: 2026-07-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Ruoli

Wu, Wantao

Wu, Xuan

Yuan, Ye

Zhang, Zhongyi

Chen, Junyi

Xie, Yuxin

Zhang, Linhui

Yu, Xinrui

Zhang, Hao https://orcid.org/0000-0002-4582-2556
Xie, Zongyi
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82471321)

Natural Science Foundation of Chongqing Municipality (CSTB2023NSCQ-MSX0107)

Natural Science Foundation of Chongqing Municipality (CSTB2025NSCQ-GPX1144)

Chongqing Medical Leading Talents Program (YXLJ202429)

Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (20241708)
License Information

Text and Data Mining valid from 2026-07-11

Accepted Manuscript valid from 2026-07-11
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Article History

Received: 7 February 2026

Accepted: 26 June 2026

First Online: 11 July 2026

Declarations

:

: Not applicable.

: All authors have agreed on the contents of the manuscript.

: All authors declare that they have no competing interests.

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