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Authors
Tian, Yizhuo
Geng, Jing
Wang, Mingyao
Zhu, Wenfeng
Xu, Jiyu
Tang, Xiaoyue
Wang, Qiaochu
Ding, Tao
Zhang, Luyao
Zhang, Zhiyi
Shi, Chunmei
Yang, Huilan
Gao, Yafei
Wu, Yue
Liu, Jiangfeng
Yang, Juntao
Dai, Huaping
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Funding
Funding for this research was provided by:
Key Technologies Research and Development Program (2023YFC2507102)
National Natural Science Foundation of China (823B2001)
National Natural Science Foundation of China (82341064,82090010, 82090011)
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS2021-I2M-1-049)
Haihe Laboratory of Cell Ecosystem Innovation Fund (22HHXBSS00008 and 22HHKYZX0034)
State Key Laboratory Special Fund (2060204)
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Article History
Received: 26 February 2026
Accepted: 7 July 2026
First Online: 17 July 2026
Declarations
Ethics approval: The study protocol was approved by the Institutional Ethics Committee of China-Japan Friendship Hospital, Beijing, China (No. 2017-25-1) and conducted in accordance with the principles of the Declaration of Helsinki. Baseline questionnaires and clinical data were collected after obtaining voluntary informed consent from all participants.
Consent for publication: Not applicable.
Competing interests: The authors declare that they have no competing interests.
Other information: The word count for the abstract is 261. The word count for the text is 6230. The manuscript contains 4 figures and 1 table. The number of Supplementary materials is 5. The number of references is 60.
