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Modulating mesenchymal stromal cells chondrogenesis through TGF-β1 pre-conditioning during monolayer expansion in pellet culture and in a 3D mechanical load model

Crossref DOI link: https://doi.org/10.1186/s12967-026-08719-5

Published Online: 2026-07-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Schlittler, Maja

Chen, Guoliang

Ievina, Lauma

Mecchi, Laura

Breulmann, Franziska L.

Stoddart, Martin J.

Della Bella, Elena https://orcid.org/0000-0001-5151-7390
Funding

Funding for this research was provided by:

AO Foundation (AO Foundation)

Chinese-Swiss Young Researchers' Exchange Programme (EG-CN_04-032019)

China Scholarship Council (201906380175)

Horizon 2020 Research and Innovation program (857287)
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Text and Data Mining valid from 2026-07-30

Version of Record valid from 2026-07-31
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Article History

Received: 3 November 2025

Accepted: 23 July 2026

First Online: 30 July 2026

Declarations

Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki. Human BMSCs were isolated from bone marrow aspirates with informed consent and full ethical approval (Ethik-Kommission der Albert-Ludwigs-Universität Freiburg 135/14).

Consent for publication: Not applicable.

Competing interests: The authors declare that they have no competing interests.

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