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Article History

Received: 4 July 2022

Accepted: 24 August 2022

First Online: 7 September 2022

Declarations

:

: The study is conducted in accordance with the Declaration of Helsinki, the International Conference on Harmonisation Guidelines for Good Clinical Practice and local regulations. An institutional review board or independent ethics committee at each site approved the protocol, consent form and any other written information provided to patients or their legal representatives.

: All patients or their legal representatives gave written informed consent/assent prior to study entry as per local requirements of the participating centres.

: Marco Burrone, Marta Mazzoni, Roberta Naddei, Angela Pistorio, Maddalena Spelta, Marco Garrone, Maria Lombardi, Elisa Patrone, Silvia Scala, Luca Villa have no conflicts of interest to disclose.Nicolino Ruperto has received honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: 2 Bridge, Amgen, AstraZeneca, Aurinia, Bayer, Brystol Myers and Squibb, Celgene, inMed, Cambridge Healthcare Research, Domain Therapeutic, EMD Serono, Glaxo Smith Kline, Idorsia, Janssen, Eli Lilly, Novartis, Pfizer, Sobi, UCB.The IRCCS Istituto Giannina Gaslini (IGG), where NR works as full-time public employee, has received contributions from the following industries in the last 3 years: Bristol Myers and Squibb, Eli-Lilly, F Hoffmann-La Roche, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties.Angelo Ravelli has received honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: AbbVie, Angelini, BMS, Pfizer, Hoffman LaRoche, Novartis, Pfizer, Reckitt Benckiser.Alessandro Consolaro reports Investigator initiated research grant from Pfizer and Alfa Sigma and speaker’s bureaus from Pfizer.