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Article History

Received: 7 February 2018

Accepted: 29 May 2018

First Online: 13 June 2018

Ethics approval

: An agreement was obtained from The High Council of Biotechnology for transgenic animals in 2011 and renewed in 2015 (agreement number: 2040). All animal care and experimental procedures conformed with the French Decret number 2013-118, 1 February 2013 NOR: AGRG1231951D in accordance with the European Community guidelines (directive 2010/63/UE). In France, any sampling of biological material in animals for ex vivo experimentation does not require prior agreement of the ethics committee (COMOTHEA Poitou Charentes).

: Technology Transfer Accelerating Company “SATT Grand Centre ()” financially enabled the maturation of the mouse blood-brain barrier model (BBB) developed by the co-inventors (Guylène PAGE, Emilie DUGAST, Hanitriniaina RABEONY, Damien CHASSAING, and Thierry JANET). The results described in this article were obtained using this BBB model which a patent is under pending approval (FR17/57643). The other authors declare no conflict of interest.

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