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Article History

Received: 26 September 2018

Accepted: 7 January 2019

First Online: 21 February 2019

Ethics approval and consent to participate

: The project has been considered by the Norwegian Regional Ethics Committee (approval number for the DDI project: 2013/115, approval number for the genetic analysis (APGEM): 2014/1164, approval number for the biobank: 2011/1051). The local data protection officer at Akershus University Hospital has also approved the study with the according approval number 13-056, 14-156 and 13-088. Data handling was in accordance with local and national regulations, with security precautions for storage and regulated biobank facilities. Both sexes are equally included, patients and controls give informed consent to participate in the study. The DDI has a patient and caregiver representative in the steering group. User participation is ensured with open meetings and written information.

: Not applicable.

: Dr. Aarsland has received research support and/or honoraria from Astra-Zeneca, H. Lundbeck, Novartis Pharmaceuticals, and GE Health and serves as paid consultant for H. Lundbeck, Eisai, Heptares, and Axovant. Dag Aarsland is a Royal Society Wolfson Research Merit Award Holder and would like to thank the Wolfson Foundation and the Royal Society for their support. Dr. Fladby is inventor and co-founder of Inventor Pre Diagnostics A/S. All other authors declare that they have no competing interests.

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