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Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model

Crossref DOI link: https://doi.org/10.1186/s12974-025-03564-7

Published Online: 2025-10-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lei, Chenxu

Zhang, Bocheng

Yamaguchi, Junji

Tamura, Risako

Zhong, Weitong

Cao, Xingyu

Liu, Yunhui

Seki, Masahide

Suzuki, Yutaka

Suzuki, Kuninori

Tanida, Isei

Uchiyama, Yasuo

Hisatsune, Tatsuhiro
Funding

Funding for this research was provided by:

JST SPRING (JPMJSP2108)

Japan Society for the Promotion of Science (21H02152)
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Text and Data Mining valid from 2025-10-21

Version of Record valid from 2025-10-21
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Article History

Received: 18 July 2025

Accepted: 18 September 2025

First Online: 21 October 2025

Declarations

:

: All animal procedures and experiments in this study were approved by the ethical committee of the University of Tokyo (C-20-2) and were conducted according to the guidelines for animal experimentation required by the University of Tokyo.

: The authors declare no competing interests.

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