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Authors
Caceres-Palomo, Laura
Sanchez-Mejias, Elisabeth
Trujillo-Estrada, Laura
Perez-Moreno, Juan Jose
Lopez-Oliva, Elba
Lim, Tau En
DeFlitch, Leah
Chang, Serena H.
Kampman, Lucas
Corces, M. Ryan
Blurton-Jones, Mathew
Moreno-Gonzalez, Ines
Pascual, Alberto
Vitorica, Javier
Garcia-Leon, Juan Antonio
Gutierrez, Antonia
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Funding
Funding for this research was provided by:
Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (UMA20-FEDERJA-048 (to JAGL), PY18-RT-2233 (to AG), SNGJ4-11 (to LCP))
Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (UMA20-FEDERJA-048 (to JAGL), PY18-RT-2233 (to AG), SNGJ4-11 (to LCP))
Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (UMA20-FEDERJA-048 (to JAGL), PY18-RT-2233 (to AG), SNGJ4-11 (to LCP))
National Institutes of Health (P30 AG066519)
National Institutes of Health (P01AG073082, U01AG072573, and UM1HG012076 to MRC.)
National Institutes of Health (P30 AG066519)
Instituto de Salud Carlos III (PI21/00915 and PI24/00274 (to AG) and PI21/00914 and PI24/00308 (to JV))
Instituto de Salud Carlos III (PI21/00915 and PI24/00274 (to AG) and PI21/00914 and PI24/00308 (to JV))
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
Consejería de Salud y Familias, Junta de Andalucía (PI-0276-2018 (to JAGL))
Universidad de Málaga (B1-2020_04 (to JAGL))
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Article History
Received: 11 July 2025
Accepted: 22 October 2025
First Online: 12 December 2025
Declarations
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: Human iPSC lines were generated by the University of California, Irvine Alzheimer’s Disease Research Center (UCI ADRC) Induced Pluripotent Stem Cell Core under approved Institutional Review Boards (IRB) and human Stem Cell Research Oversight (hSCRO) committee protocols. The experimentation with human iPSCs was approved by the ethical committees of the University of Malaga (CEUMA: 101-2018-T) and the Spanish Instituto de Salud Carlos III (requests 491_396_1 and 500_405_1).Frontal cortex (lateral prefrontal region) samples were obtained from the Neurological Tissue Bank BioBanco-Hospital clínico-IDIBAPS (Barcelona, Spain). This study was approved by the Portal de Etica de la Investigacion Biomedica de Andalucia (PEIBA) de la Consejeria de Salud from Andalucia (Spain), as well as by the corresponding biobank ethics committees.
: Not applicable.
: The authors declare no competing interests.
