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FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice

Crossref DOI link: https://doi.org/10.1186/s12974-025-03678-y

Published Online: 2026-02-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chen, Zheping https://orcid.org/0009-0000-0677-2894
Wu, Qianqian https://orcid.org/0009-0009-2602-7299
Ma, Jiahui

Shi, Yufei

Zhang, Qian

Wu, Huanghui

Zhang, Yuxin

Li, Zhouxiang

Ruan, Xianghan

Xiong, Lize

Cong, Peilin https://orcid.org/0000-0002-4522-0272
Tian, Li https://orcid.org/0009-0007-5272-013X
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82401497)

National Natural Science Foundation of China (82301370)

National Natural Science Foundation of China (82222019)

“Medicine + X” Interdisciplinary Research Program of Tongji University (2025-0674-ZD-01)
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Text and Data Mining valid from 2026-02-11

Version of Record valid from 2026-04-22
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Article History

Received: 3 November 2025

Accepted: 23 December 2025

First Online: 11 February 2026

Declarations

:

: All experiments involving animals were conducted according to the ethical policies and procedures approved by the Tongji University’s Animal Care and Use Committee in Shanghai, China (Approval No: TJBH13724508). Cognitive function assessment and blood sample collection, in surgical patients were approved by Peking University Institutional Review Board (Approval No: 00001052–110488), and have been registered in the Chinese Clinical Trial Registry (ChiCTR-TRC-09000543) and Clinical Trials. Gov (identifier: NCT01661907). Each participant received a written informed consent.

: Not applicable.

: The authors declare no competing interests.

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