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IL-27, a metabolic regulator secreted by astrocytes in response to GLP-1RA OHP2, modulates microglial reprogramming in Alzheimer’s disease by regulating cGAS lactylation

Crossref DOI link: https://doi.org/10.1186/s12974-025-03683-1

Published Online: 2026-01-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Du, Yixuan

Wu, Lingxi

Mao, Yang

Chen, Song

Gao, Xiangdong
Funding

Funding for this research was provided by:

National Natural Science Foundation of China,China (82473834)

National Natural Science Foundation of China,China (82373780)

“Double First-Class” University Project (CPU2022PZQ10)
License Information

Text and Data Mining valid from 2026-01-13

Version of Record valid from 2026-02-09
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Article History

Received: 16 September 2025

Accepted: 26 December 2025

First Online: 13 January 2026

Declarations

:

: The authors declare no competing interests.

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