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Authors
Guo, Hai-Hua https://orcid.org/0009-0003-9383-4361
Su, Dan https://orcid.org/0000-0002-6090-5990
Song, Bo https://orcid.org/0009-0001-0236-1446
Geng, Zhi https://orcid.org/0000-0002-5948-6215
Wang, Lu https://orcid.org/0000-0002-0184-9570
Wang, Wen https://orcid.org/0000-0003-0986-8853
Hu, Wenjie https://orcid.org/0000-0003-1795-1710
Li, Xiaoxue
Li, Weiqiang
Zhang, Gu https://orcid.org/0009-0007-9952-6027
Fang, Miao https://orcid.org/0009-0003-0109-8695
Dai, Yulong https://orcid.org/0009-0009-9633-4614
Hu, Panpan https://orcid.org/0000-0002-1683-2739
Wu, Xingqi https://orcid.org/0000-0003-0646-1353
Wang, Kai https://orcid.org/0000-0002-6197-914X
Wei, Ling https://orcid.org/0000-0001-5794-8749
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Funding
Funding for this research was provided by:
Anhui Provincial Department of Education Scientific Research Project for Doctoral Students (2025AHGXZK50040)
Natural Science Foundation of China (82101498)
Natural Science Foundation of China (82090034)
Natural Science Foundation of China (82371201)
2021 Youth Foundation training program of the First Affiliated Hospital of Anhui Medical University (2021kj19)
Anhui Province Clinical Medical Research Transformation Special Project (202204295107020006)
Natural Science Foundation of the Xizang Autonomous Region Group Medical Aid Project to Xizang (XZZR202402048)
Research Fund of Anhui Institute of Translational Medicine (2022zhyx-B11)
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Article History
Received: 8 December 2025
Accepted: 26 February 2026
First Online: 7 March 2026
Declarations
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: The entire approval for this study was obtained from the Eisai Ethics Committee (2017 − 0433). Following the Declaration of Helsinki, written informed consent was obtained from all participants or their guardians. Author disclosures are available in the supporting information.
: Not applicable.
: The authors declare no competing interests.
