Chiang, Wesley
Li, Herman
Le, Linh
David-Bercholz, Jennifer
Caceres, Ana I.
Ahmad, Danial
Squire, Erica
Stecyk, Kamryn S.
Marrero, Mariah
Pereira, Amanda
Squire, Rene
Lim, Claire
McGrath, James L.
Majewska, Ania K.
Terrando, Niccolò
Gelbard, Harris A.
Funding for this research was provided by:
National Institute of General Medical Sciences, United States (T32GM135134)
National Institute on Aging (T32AG076455)
National Institute on Aging (RF1AG079138)
National Institute on Aging (RF1AG079138)
National Institute on Aging (RF1AG079138)
National Institute of Neurological Disorders and Stroke (R01NS114480)
Alzheimer's Association (AARG-NTF-19-619116)
Article History
Received: 3 September 2025
Accepted: 10 March 2026
First Online: 25 March 2026
Declarations
:
: All procedures involving mice were performed under strict compliance to protocols approved by the Institutional Animal Care and Use Committees at both Duke University Medical Center (DUMC) and University of Rochester Medical Center (URMC) and developed in accordance with the National Research Council Guide for the Care and Use of Laboratory Animals, 8th edition [ ]. Duke University and the University of Rochester Medical Center are AAALAC-accredited institutions.The use of human iPSCs (WiCell; cat: iPS(IMR90)-4) and human neutrophils isolated from whole blood collected from consenting donors was conducted under strict adherence to a protocol approved by the Institutional Review Board at the University of Rochester (protocol #00004777).
: JLM is the Co-Founder and Corporate Director of SiMPore but received no support for experiments described in this study; HAG is the Chief Science Officer of Pioneura Corp. but received no support for this study.