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Authors
Liu, Huilin
Hu, Chun
Liu, Hongdou
Gong, Ziqing
Jiang, Shilong
Xie, Junkai
Li, Yongtao
Liu, Chong
Wang, Ying
Zou, Chan
Yang, Guoping
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Funding
Funding for this research was provided by:
the Natural Science Foundation of Hunan Province (2023JJ40952)
the Natural Science Foundation of Hunan Province (2024JJ6618)
Foundation for Innovative Research Groups of the National Natural Science Foundation of China (82204733)
Health Research Project of Hunan Provincial Health (20254677)
the National Natural Science Foundation of China (82474009)
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Article History
Received: 17 December 2025
Accepted: 9 April 2026
First Online: 7 May 2026
Declarations
:
: Not applicable.
: The authors declare no competing interests.
: This table summarizes representative compounds reported to target or modulate the cGAS–STING axis in neurodegenerative disease models. Included agents comprise direct cGAS or STING inhibitors as well as indirect modulators that reduce upstream DNA stress, restore mitophagy or autophagy, or dampen downstream inflammatory amplification. Disease context, validated cell type, animal model, and key supporting references are listed where directly supported by the cited literature.
