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Versatile HIV Rev-dependent reporter cell system for stringent and sensitive quantification of viral reservoirs, neutralizing antibodies, and restriction factors

Crossref DOI link: https://doi.org/10.1186/s12977-026-00675-8

Published Online: 2026-02-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Spear, Mark

Choi, Joseph

Hetrick, Brian

Lee, JeongHwan

Lê-Bury, Gabrielle https://orcid.org/0000-0002-4650-5990
Vo, Thuy T.

Han, Yang https://orcid.org/0009-0006-6844-1349
Liang, Huizhi

Guo, Jia

Yu, Dongyang

Iyer, Subashini

Mwandumba, Henry C. https://orcid.org/0000-0003-4470-3608
Russell, David G. https://orcid.org/0000-0002-9748-750X
Wu, Yuntao https://orcid.org/0000-0002-9547-3278
Gludish, David W. https://orcid.org/0000-0002-3537-4585
Funding

Funding for this research was provided by:

Wellcome Trust (088696/Z/09/Z)

National Institute of Allergy and Infectious Diseases (AI176575)

National Institute of Allergy and Infectious Diseases (R01AI148012)

Office of Research Infrastructure Programs (K01OD031968)
License Information

Text and Data Mining valid from 2026-02-11

Version of Record valid from 2026-02-13
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Article History

Received: 16 September 2025

Accepted: 20 January 2026

First Online: 11 February 2026

Declarations

:

: Patents related to the Rev-dependent vector have been filed by George Mason University. Y.W. and B.H. are board members and shareholders of Virongy Biosciences. All other authors declare they have no competing interests.

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