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Article History

Received: 7 November 2017

Accepted: 6 February 2018

First Online: 27 February 2018

Ethics approval and consent to participate

: Approval has been obtained by the competent Ethics Committees of IRCCS San Raffaele Pisana, Rome, and of the Liguria Region.All eligible patients admitted to the spa received detailed information about the study by the physician in charge of the treatment, and thereafter were asked to sign an informed consent. Only patients who accepted to participate to the study and signed the consent form were requested to donate biological samples and were administered the questionnaire.

: Not applicable.

: The authors declare that they have no competing interests.

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