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Article History

Received: 18 March 2025

Accepted: 17 June 2025

First Online: 3 July 2025

Change Date: 18 July 2025

Change Type: Update

Change Details: Affiliation 1 has been updated.

Declarations

:

: The SI cohort is was conducted in compliance with all pertinent legislation and directives and following the guidelines on human biobanks for research and other relevant directives on research ethics. Special emphasis is placed on privacy, safety of data, genetic information and reporting of incidental medical findings to participants. Ethics committee of Hannover Medical School (MHH), Hannover, Germany, gave ethical approval for this work (No 8615_BO_S_2019; connected disease cohorts under the file references 8730_BO_S_2019 and 8733_BO_S_2019). The study was conducted according to the principles of declaration of Helsinki. Participants gave their written informed consent prior to the study.

: This manuscript does not contain personal information about any of the study participants.

: The authors declare no competing interests.

: Study design: L.R., T.W. Experiments: L.R. Data analysis: L.R., S.T. Data interpretation: L.R., B.B., R.F., J.H., T.W. Writing of the first draft: L.R. Editing and revising: all authors. Supervision: R.F., T.W.