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Authors
Joodaki, Mahyar
Rodgers, Griffin
Hopf, Alois
Koller, Mathias R.
Guzman, Raphael
Santarnecchi, Emiliano
Vögerl, Johannes S.
Ferchow, Julian
Ruffner, Annina
Funken, Marc
Meboldt, Mirko
Osmani, Bekim
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Funding
Funding for this research was provided by:
Bottneuro AG, Switzerland
Innosuisse - Schweizerische Agentur für Innovationsförderung (102.809 IP-ENG)
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Article History
Received: 19 March 2025
Accepted: 4 October 2025
First Online: 24 November 2025
Declarations
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: The study was approved by the Independent Competent Ethics Committee (Ethikkommission Nordwest-und Zentralschweiz (EKNZ)) by the 14 August 2023 and Competent Regulatory Authority Swissmedic by the 20 December 2023 (BASEC No: 2023-D0054). All participants provided their written informed consent to participate in the study before the participant was enrolled in the study and subjected to any investigation-related procedure. The investigation was carried out in accordance to the approved protocol and its amendments, the World Medical Association Declaration of Helsinki (64th WMA General Assembly, Fortaleza, Brazil, October 2013) and Swiss law.
: Not applicable.
: M.J., G.R., A.H., M.R.K., R.G., A.R., M.F. and B.O. receive monetary and/or equity or stock from Bottneuro AG. B.O. is a board member of Bottneuro AG. M.J. and B.O. are coinventors on two patents #EP4204077B1 and #EP4282464B1 issued to Bottneuro AG. R.G and E.S., has consulting and/or advisory agreement with Bottneuro AG. The other authors declare that they have no competing interests.
