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Article History

Received: 7 September 2017

Accepted: 18 January 2018

First Online: 30 January 2018

Ethics approval and consent to participate

: The study was approved by the relevant Institutional Review Board or Independent Ethics Committee at each study centre and met the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. All patients provided informed, written consent to participate.

: Not applicable

: FZ has provided consulting and has participated as a speaker for AbbVie, Bristol-Myers Squibb, Gilead Sciences, Janssen and MSD. CM has received grant support from AbbVie, Gilead Sciences and Janssen, and has participated as a speaker or advisor for AbbVie, Bristol-Myers Squibb, Gilead Sciences, Intercept, Janssen and MSD. SSL has received grant support and has provided consulting for AbbVie, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Intercept, Janssen, Merck, Novartis, Pendopharm and Roche, and has participated in a speakers bureau for AbbVie, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck and Pendopharm. PB has participated in a speakers’ bureau or advisory board for AbbVie, Bristol-Myers Squibb, Falk, Gilead Sciences, Janssen, Merz Pharma and MSD. AH has no conflicts of interest to disclose. EL has received grant support from AbbVie, Achillion Pharmaceuticals, Boehringer Ingelheim, Bristol-Myers Squibb, Enanta Pharmaceuticals, Gilead Sciences, GlaxoSmithKline, Janssen, Merck & Co., Roche, Salix, Santaris Pharmaceuticals, Tacere and Theravance, has acted as a consultant for AbbVie, Achillion Pharmaceuticals, Bristol-Myers Squibb, Enanta, Gilead Sciences, Janssen, Merck & Co., Novartis, Santaris Pharmaceuticals, Regulus, and Theravance, and has participated in sponsored lectures for AbbVie, Bristol-Myers Squibb, Gilead, Janssen and Merck & Co. CC, OL, BF, TV, US and WJ are employees of Janssen and may be shareholders of Johnson & Johnson.

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