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Article History

Received: 12 October 2017

Accepted: 5 February 2018

First Online: 2 March 2018

Ethics approval and consent to participate

: The study was conducted according to national and international ethical guidelines (good clinical practice, Nuremberg statements, Declaration of Helsinki) and local regulatory rules (Mercosur Standards/GMC/RES No. 129/96). The protocol was approved by the Ethics Committee of the Hospital de Clínicas on October 24th (2014) and all patients gave written informed consent. Access to personal information was restricted to the medical doctors. The genetic information extracted from the samples was used exclusively for the purposes of this study.

: Not applicable.

: The authors declare that they have no competing interests.

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