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Authors
Bermudez, Camilo
Hofrenning, Ekaterina
Fought, Angela J.
Gunter, Jeffrey L.
Cogswell, Petrice M.
Jones, David T.
Schwarz, Christopher G.
Lowe, Val
Elder, Benjamin D.
Petersen, Ronald C.
Vemuri, Prashanthi
Algeciras-Schimnich, Alicia
Mielke, Michelle M.
Knopman, David S.
Graff-Radford, Neill R.
Jack, Clifford R. Jr
Graff-Radford, Jonathan
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Funding
Funding for this research was provided by:
National Institute on Aging (P30 AG062677)
National Institute on Aging (U01 AG006786)
National Institute on Aging (U01 AG006786)
National Institute on Aging (P30 AG062677)
National Institute on Aging (U01 AG006786)
National Institute on Aging (RF1 AG069052)
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Article History
Received: 15 September 2025
Accepted: 2 March 2026
First Online: 5 March 2026
Declarations
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: This study was approved by the Mayo Clinic Institutional Review Board and the Olmsted Medical Center Institutional Review Board. All procedures were conducted in accordance with the Declaration of Helsinki and its later amendments. Written informed consent was obtained from all participants included in this study.
: PMC has received honoraria from Eisai. She serves on DSMB for Eisai and Lilly but receives no compensation to self or institution. BDE: Consultant for Amgen, SI Bone, Depuy Synthes, Iota Biosciences; Clinical Trial Funding from SI Bone, Stryker, and Medimaps; Royalty agreement with SI Bone and Elsevier; Stock in Injectsense; Medical Advisory Board for Injectsense. AA-S has participated in advisory boards for Roche Diagnostics, Fujirebio Diagnostics and Siemens Healthineers, and has received speaker honoraria from Roche Diagnostics and Eli Lilly. JGR is in the DSMB for NINDS strokeNET. He is also a site investigator for trials sponsored by Eisai and Cognition therapeutics. CGS receives research funding from the NIH. VL serves as a consultant for Bayer Schering Pharma, Piramal Life Sciences, Life Molecular Imaging, Eisai Inc., AVID Radiopharmaceuticals, Eli Lilly and Company, PeerView Institute for Medical Education, and Merck Research and receives research support from GE Healthcare, Siemens Molecular Imaging, AVID Radiopharmaceuticals, and the NIH (NIA, NCI). MMM has served on scientific advisory boards and/or has consulted for Acadia, Althira, Biogen, Cognito Therapeutics, Eisai, Lilly, Merck, Novo Nordisk, Neurogen Biomarking, and Roche; received speaking honorariums from Novo Nordisk, PeerView Institute, and Roche; and receives grant support from the National Institute of Health, Department of Defense, Alzheimer’s Association, and Davos Alzheimer’s Collaborative. CRJ receives no compensation from any commercial entity. He receives research support from NIH, the GHR Foundation, and the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Clinic.
