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A dual GLP-1/GIP agonist inhibits oxidative stress in diabetic rats with cerebral ischemia-reperfusion injury by activating the Nrf2/ARE signaling pathway

Crossref DOI link: https://doi.org/10.1186/s12987-026-00874-7

Published Online: 2026-09-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Bai, Bo

Han, YuDi

Feng, Peng

Li, DongFang

Xue, GuoFang

Guo, YaNan

Guo, Hui

Gao, HuiZhong

Wang, YaNan

Liu, ZhaoNa

Hölscher, Christian https://orcid.org/0000-0002-8159-3260
Funding

Funding for this research was provided by:

Natural Science Foundation of Shanxi Province (20210302124692)
License Information

Text and Data Mining valid from 2026-09-05

Accepted Manuscript valid from 2026-09-05
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Article History

Received: 7 June 2026

Accepted: 31 August 2026

First Online: 5 September 2026

Declarations

Ethical approval: All experimental protocols were approved by the Ethics Committee of Shanxi Medical University and performed in accordance to the National Institute of Health (NIH) guidelines (NIH Publication, No. 80 − 23, revised 1978). All efforts were made to minimize the number of animals used and their suffering. The ARRIVE guidelines have been followed.

Competing interests: The authors declare no competing interests.

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