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Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure

Crossref DOI link: https://doi.org/10.1186/s12989-019-0303-7

Published Online: 2019-07-09

Published Print: 2019-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kreyling, Wolfgang G. https://orcid.org/0000-0002-0702-6567
Holzwarth, Uwe https://orcid.org/0000-0002-7382-6837
Schleh, Carsten

Hirn, Stephanie

Wenk, Alexander

Schäffler, Martin

Haberl, Nadine

Semmler-Behnke, Manuela

Gibson, Neil https://orcid.org/0000-0002-0643-1739
Funding

Funding for this research was provided by:

Deutsche Forschungsgemeinschaft (SPP 1313)

Seventh Framework Programme (NMP4-SL-2008-214547, NMP4-SL-2009-228789, NMP-2008-1.3-2 CP-FP 228625-2)
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Text and Data Mining valid from 2019-07-09

Version of Record valid from 2019-07-09
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Article History

Received: 15 January 2019

Accepted: 30 April 2019

First Online: 9 July 2019

Ethics approval and consent to participate

: This study did not involve any human participants, human data or human tissue.All experiments on rats were conducted under German federal guidelines for the use and care of laboratory animals in accordance with EU Directive 2010/63/EU for animal experiments. They were approved by the Regierung von Oberbayern (Government of District of Upper Bavaria, Approval No. 211–2531-94/04) and by the Institutional Animal Care and Use Committee of the Helmholtz Centre Munich.

: Not applicable.

: The authors declare that they have no competing interests. The authors alone are responsible for the content and writing of the manuscript.

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