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Authors
Guglielmi, Angelo
Graziano, Francesca
Fornoni, Anna
Mangili, Paolo
Picetti, Edoardo
Baggiani, Marta
Chesnut, Randall M.
Hawryluk, Gregory W. J.
Newcombe, Virginia F. J.
Rebora, Paola
Galimberti, Stefania
Citerio, Giuseppe https://orcid.org/0000-0002-5374-3161
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Clinical Trials BETA
Clinical trials referenced in this document:
nct02210221 at ClinicalTrials.govDocuments that mention this clinical trial
Comparative effectiveness of surgery in traumatic acute subdural and intracerebral haematoma: study protocol for a prospective observational study within CENTER-TBI and Net-QuRe
https://doi.org/10.1136/bmjopen-2019-033513
Prognostic value of global deep white matter DTI metrics for 1-year outcome prediction in ICU traumatic brain injury patients: an MRI-COMA and CENTER-TBI combined study
https://doi.org/10.1007/s00134-021-06583-z
Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study
https://doi.org/10.1186/s13054-022-04079-w
Association of lifesaving versus non-lifesaving extracranial surgery with long-term outcome after severe traumatic brain injury: a prospective CENTER-TBI cohort analysis
https://doi.org/10.1186/s13017-026-00713-y
High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI
https://doi.org/10.1007/s00134-022-06884-x
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Funding
Funding for this research was provided by:
European Commission (EC grant 602150)
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Article History
Received: 24 March 2026
Accepted: 5 July 2026
First Online: 10 July 2026
Declarations
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: The CENTER-TBI study was performed according to the Helsinki Declaration and the International Conference on Harmonisation for Good Clinical Practice. Since comatose patients could not provide informed consent during study recruitment, each centre referred to local/national law on the lack of capacity. If the patients regained capacity at the follow-up visit, they had to either provide informed consent to use the acute and follow-up data or refuse to participate in the research. Ethical approval for the study was obtained from the Medical Ethics Committees of each participating centre, and informed consent was obtained from all participants following local regulations ( ). For this sub analysis, no further ethical approval was required.
: Written informed consent for the publication of these data has been previously obtained.
: GC reports grants and personal fees as a Speakers' Bureau Member and Advisory Board Member from Integra and NeurOptics, all outside the submitted work. VFJN holds investigator-led grants with Abbott and Roche Pharmaceuticals and in-kind support from UPFRONT Diagnostics, all outside the submitted work. The other authors declare no competing interests.
