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RANKL-mediated osteoclastic subchondral bone loss at a very early stage precedes subsequent cartilage degeneration and uncoupled bone remodeling in a mouse knee osteoarthritis model

Crossref DOI link: https://doi.org/10.1186/s13018-025-05578-6

Published Online: 2025-03-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hashimoto, Teruaki

Akagi, Masao

Tsukamoto, Ichiro

Hashimoto, Kazuhiko

Morishita, Takafumi

Ito, Tomohiko

Goto, Koji
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Text and Data Mining valid from 2025-03-03

Version of Record valid from 2025-03-03
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Article History

Received: 17 November 2024

Accepted: 5 February 2025

First Online: 3 March 2025

Declarations

:

: All animal experimental procedures were performed in accordance with the guidelines of the National Institutes of Health and the institutional rules for the use and care of laboratory animals at Kindai University. All procedures were approved by the Experimental Animal Welfare Committee of Kindai University (approval number: KAME-2022-008). Consent to participate was not required.

: Not applicable.

: The authors declare that they have no competing interests.

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