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Omeprazole exacerbates intervertebral disc degeneration through Caspase-3 mediated apoptosis of nucleus pulposus cells: a Mendelian randomization, network toxicology, and in vitro experimental study

Crossref DOI link: https://doi.org/10.1186/s13018-025-05863-4

Published Online: 2025-05-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Jia, Yuchao

Zhao, Haifan

Huang, Shengbo

Xu, Baoshan
Funding

Funding for this research was provided by:

Tianjin Municipal Health Commission (TJWJ2023XK023)
License Information

Text and Data Mining valid from 2025-05-03

Version of Record valid from 2025-05-03
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Article History

Received: 13 March 2025

Accepted: 26 April 2025

First Online: 3 May 2025

Declarations

:

: The animal experiment of the study was approved by the Tianiin Jinke Bona Biotechnology Co.,LTD (GENINK-20250006).

: Not applicable.

: The authors declare no competing interests.

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